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Journal article

Dissecting the fibrillin microfibril: structural insights into organization and function.

Abstract:

Force-bearing tissues such as blood vessels, lungs, and ligaments depend on the properties of elasticity and flexibility. The 10 to 12 nm diameter fibrillin microfibrils play vital roles in maintaining the structural integrity of these highly dynamic tissues and in regulating extracellular growth factors. In humans, defective microfibril function results in several diseases affecting the skin, cardiovascular, skeletal, and ocular systems. Despite the discovery of fibrillin-1 having occurred m...

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Publication status:
Published

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Publisher copy:
10.1016/j.str.2011.12.008

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Journal:
Structure (London, England : 1993)
Volume:
20
Issue:
2
Pages:
215-225
Publication date:
2012-02-01
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
Source identifiers:
254297
Language:
English
Keywords:
Pubs id:
pubs:254297
UUID:
uuid:8c346e66-0561-4bdb-a1d7-b2cfc3a6323c
Local pid:
pubs:254297
Deposit date:
2012-12-19

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