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A fibrocontractive mechanochemical model of dermal wound closure incorporating realistic growth factor kinetics

Abstract:

Fibroblasts and their activated phenotype, myofibroblasts, are the primary cell types involved in the contraction associated with dermal wound healing. Recent experimental evidence indicates that the transformation from fibroblasts to myofibroblasts involves two distinct processes: The cells are stimulated to change phenotype by the combined actions of transforming growth factor β (TGFβ) and mechanical tension. This observation indicates a need for a detailed exploration of the effect of the ...

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Publisher:
Springer
Publication date:
2012-01-01
UUID:
uuid:8c331daf-9fd5-4804-9515-0092653912da
Local pid:
oai:eprints.maths.ox.ac.uk:1506
Deposit date:
2012-04-04

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