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A fibrocontractive mechanochemical model of dermal wound closure incorporating realistic growth factor kinetics

Abstract:

Fibroblasts and their activated phenotype, myofibroblasts, are the primary cell types involved in the contraction associated with dermal wound healing. Recent experimental evidence indicates that the transformation from fibroblasts to myofibroblasts involves two distinct processes: The cells are stimulated to change phenotype by the combined actions of transforming growth factor β (TGFβ) and mechanical tension. This observation indicates a need for a detailed exploration of the effect of the ...

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K. E. Murphy More by this author
C. L. Hall More by this author
P. K. Maini More by this author
S. W. McCue More by this author
McElwain D L Sean More by this author
Publication date:
2012
URN:
uuid:8c331daf-9fd5-4804-9515-0092653912da
Local pid:
oai:eprints.maths.ox.ac.uk:1506

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