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Journal article

Corticotropin-releasing factor receptor 1 activation during exposure to novelty stress protects against Alzheimer's disease-like cognitive decline in AβPP/PS1 mice.

Abstract:

A lifestyle rich in physical and mental activities protects against Alzheimer's disease (AD) but the underlying mechanisms are unclear. We have proposed that this is mediated by a stress response and have shown that repeated exposure to novelty stress, which induces physical and exploratory activities, delays the progression of AD-like pathology in the TASTPM mouse model. Here, we aimed to establish the role played by corticotrophin-releasing factor receptor 1 (CRFR1), a major component of th...

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Publication status:
Published

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Publisher copy:
10.3233/jad-122164

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
Journal:
Journal of Alzheimer's disease : JAD
Volume:
34
Issue:
3
Pages:
781-793
Publication date:
2013-01-01
DOI:
EISSN:
1875-8908
ISSN:
1387-2877
Language:
English
Keywords:
Pubs id:
pubs:433468
UUID:
uuid:8c2d2ad9-3b28-49bc-a19e-f4605d1de778
Local pid:
pubs:433468
Source identifiers:
433468
Deposit date:
2013-11-16

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