Journal article
Decreased STARD10 expression is associated with defective insulin secretion in humans and mice
- Abstract:
-
Genetic variants near ARAP1 (CENTD2) and STARD10 influence type 2 diabetes (T2D) risk. The risk alleles impair glucose-induced insulin secretion and, paradoxically but characteristically, are associated with decreased proinsulin:insulin ratios, indicating improved proinsulin conversion. Neither the identity of the causal variants nor the gene(s) through which risk is conferred have been firmly established. Whereas ARAP1 encodes a GTPase activating protein, STARD10 is a member of the steroidog...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
National Institute for Health Research
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Bibliographic Details
- Publisher:
- Cell Press Publisher's website
- Journal:
- American Journal of Human Genetics Journal website
- Volume:
- 100
- Issue:
- 2
- Pages:
- 238–256
- Publication date:
- 2017-01-26
- Acceptance date:
- 2016-12-20
- DOI:
- EISSN:
-
1537-6605
- ISSN:
-
0002-9297
Item Description
Terms of use
- Copyright holder:
- Carrat et al
- Copyright date:
- 2017
- Notes:
- © 2017 The Author(s). This is an open access article under the CC BY license, open access funded by Medical Research Council.
- Licence:
- CC Attribution (CC BY)
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