Conserved footprints of APOBEC3G on Hypermutated human immunodeficiency virus type 1 and human endogenous retrovirus HERV-K(HML2) sequences.

Journal article

The human polynucleotide cytidine deaminases APOBEC3G (hA3G) and APOBEC3F (hA3F) are antiviral restriction factors capable of inducing extensive plus-strand guanine-to-adenine (G-to-A) hypermutation in a variety of retroviruses and retroelements, including human immunodeficiency virus type 1 (HIV-1). They differ in target specificity, favoring plus-strand 5'GG and 5'GA dinucleotide motifs, respectively. To characterize their mutational preferences in detail, we analyzed single-copy, near-full...

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Authors: Armitage, A; Katzourakis, A; de Oliveira, T; Welch, J; Belshaw, R

• Publication status: Published
• Journal: Journal of virology
• Volume: 82
• Issue: 17
• Pages: 8743-8761
• Publication date: 2008-09-01
• DOI: 10.1128/jvi.00584-08
• EISSN: 1098-5514
• ISSN: 0022-538X
• Language: English
• Keywords: Mutation; Molecular Sequence Data; Proviruses; Sequence Homology, Nucleic Acid; Humans; Phylogeny; Cytidine Deaminase; Base Sequence; Sequence Analysis, DNA; Endogenous Retroviruses; HIV-1