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Conserved footprints of APOBEC3G on Hypermutated human immunodeficiency virus type 1 and human endogenous retrovirus HERV-K(HML2) sequences.

Abstract:

The human polynucleotide cytidine deaminases APOBEC3G (hA3G) and APOBEC3F (hA3F) are antiviral restriction factors capable of inducing extensive plus-strand guanine-to-adenine (G-to-A) hypermutation in a variety of retroviruses and retroelements, including human immunodeficiency virus type 1 (HIV-1). They differ in target specificity, favoring plus-strand 5'GG and 5'GA dinucleotide motifs, respectively. To characterize their mutational preferences in detail, we analyzed single-copy, near-full...

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Publication status:
Published

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Publisher copy:
10.1128/jvi.00584-08

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
Journal:
Journal of virology More from this journal
Volume:
82
Issue:
17
Pages:
8743-8761
Publication date:
2008-09-01
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
Language:
English
Keywords:
Pubs id:
pubs:34280
UUID:
uuid:8c26cefa-c161-40fe-868a-b781a0f9dace
Local pid:
pubs:34280
Source identifiers:
34280
Deposit date:
2012-12-19

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