- Abstract:
-
Regulation of insulin release, membrane potential, transmembrane 45Ca fluxes and cytoplasmic free Ca2+ concentration, [Ca2+]i, was examined using suspensions of transplantable NEDH rat insulinoma cells previously cultured for 2-3 days to eliminate necrotic tumour cells and counter prior hypoglycaemia. Insulinoma cells displayed a resting [Ca2+]i of 94 +/- 8 nM (n = 17) and released 104 +/- 15 ng insulin 10(-6) cells (n = 7) during 60 min incubations with uptake of 2.7 +/- 0.2 nmol 45Ca 10(-6)...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/bjc.1988.154
-
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- Journal:
- British journal of cancer
- Volume:
- 58
- Issue:
- 1
- Pages:
- 22-29
- Publication date:
- 1988-07-05
- DOI:
- EISSN:
-
1532-1827
- ISSN:
-
0007-0920
- URN:
-
uuid:8c1c4b8a-b062-4ef4-814a-da6f18146fe8
- Source identifiers:
-
20877
- Local pid:
- pubs:20877
- Copyright date:
- 1988
Journal article
Measurements of membrane potential, transmembrane 45Ca fluxes, cytoplasmic free Ca2+ concentration and insulin release by transplantable rat insulinoma cells maintained in tissue culture.
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