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Journal article

Measurements of membrane potential, transmembrane 45Ca fluxes, cytoplasmic free Ca2+ concentration and insulin release by transplantable rat insulinoma cells maintained in tissue culture.

Abstract:

Regulation of insulin release, membrane potential, transmembrane 45Ca fluxes and cytoplasmic free Ca2+ concentration, [Ca2+]i, was examined using suspensions of transplantable NEDH rat insulinoma cells previously cultured for 2-3 days to eliminate necrotic tumour cells and counter prior hypoglycaemia. Insulinoma cells displayed a resting [Ca2+]i of 94 +/- 8 nM (n = 17) and released 104 +/- 15 ng insulin 10(-6) cells (n = 7) during 60 min incubations with uptake of 2.7 +/- 0.2 nmol 45Ca 10(-6)...

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Publication status:
Published

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Publisher copy:
10.1038/bjc.1988.154

Authors


Abrahamsson, H More by this author
Arkhammar, P More by this author
Berggren, PO More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
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Journal:
British journal of cancer
Volume:
58
Issue:
1
Pages:
22-29
Publication date:
1988-07-05
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
URN:
uuid:8c1c4b8a-b062-4ef4-814a-da6f18146fe8
Source identifiers:
20877
Local pid:
pubs:20877

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