Thesis
Characterisation of the human two-pore channels
- Abstract:
-
The Ca²⁺-mobilising messenger NAADP has been shown to play a key role in the regulation of mammalian physiology. Recently, the two-pore channels (TPCs) have been proposed as an NAADP-gated Ca²⁺ channel.
Chapter 1 introduces the TPCs as the major candidates in governing NAADP-mediated Ca²⁺-release from acidic stores. Chapter 2 explains the methodologies developed and used.
Chapter 3 demonstrates the successful immunopurification of HsTPC2 and its incorporation into an artificial...
Expand abstract
Actions
Funding
Bibliographic Details
- Publication date:
- 2011
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:8c148321-5c6d-4942-ac31-3a4ca3791077
- Local pid:
- ora:5825
- Deposit date:
- 2011-10-27
Terms of use
- Copyright holder:
- Tim Funnell
- Copyright date:
- 2011
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record