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Thesis

Characterisation of the human two-pore channels

Abstract:

The Ca²⁺-mobilising messenger NAADP has been shown to play a key role in the regulation of mammalian physiology. Recently, the two-pore channels (TPCs) have been proposed as an NAADP-gated Ca²⁺ channel.

Chapter 1 introduces the TPCs as the major candidates in governing NAADP-mediated Ca²⁺-release from acidic stores. Chapter 2 explains the methodologies developed and used.

Chapter 3 demonstrates the successful immunopurification of HsTPC2 and its incorporation into an artificial...

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Research group:
Antony Galione
Oxford college:
New College
Role:
Author

Contributors

Role:
Supervisor
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Name:
British Pharmacological Society
Funding agency for:
Funnell, T
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:8c148321-5c6d-4942-ac31-3a4ca3791077
Local pid:
ora:5825
Deposit date:
2011-10-27

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