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Journal article

Systemic inflammatory response reactivates immune-mediated lesions in rat brain.

Abstract:

The potential association between microbial infection and reactivation of a multiple sclerosis (MS) lesion is an important issue that remains unresolved, primarily because of the absence of suitable animal models and imaging techniques. Here, we have evaluated this question in an empirical manner using immunohistochemistry and magnetic resonance imaging (MRI), before and after the induction of a systemic inflammatory response in two distinct models of MS. In a pattern-II-type focal myelin oli...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
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Journal:
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
29
Issue:
15
Pages:
4820-4828
Publication date:
2009-04-05
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
URN:
uuid:8c04ac63-ed09-41d4-bb93-2d3381391258
Source identifiers:
34684
Local pid:
pubs:34684

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