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Structures of soluble guanylate cyclase: implications for regulatory mechanisms and drug development.

Abstract:
Activation of cGMP synthesis leads to vasodilation, and is an important mechanism in clinical treatment of angina, heart failure, and severe peripheral and pulmonary hypertension. The nitric oxide-responsive sGC (soluble guanylate cyclase) has been the target of recent drug discovery efforts. The present review surveys recent data on the structure and regulation of sGC, and the prospects of new avenues for therapeutic intervention.
Publication status:
Published

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Publisher copy:
10.1042/bst20130228

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Role:
Author
Journal:
Biochemical Society transactions
Volume:
42
Issue:
1
Pages:
108-113
Publication date:
2014-02-05
DOI:
EISSN:
1470-8752
ISSN:
0300-5127
URN:
uuid:8c02bb06-6ca1-4545-ba13-1be90a1d777b
Source identifiers:
446810
Local pid:
pubs:446810

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