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Thesis

Selective permeabilisation of the blood-brain barrier at sites of metastasis.

Abstract:

Over one in five cancer patients will develop brain metastases and prognosis remains poor. Effective chemotherapeutics for primary systemic tumours have limited access to brain metastases owing to the blood-brain barrier (BBB). The aim of this study was to develop a strategy for specifically permeabilising the BBB at sites of cerebral metastases.

Tumour necrosis factor was injected intravenously into mouse models of haematogenously induced brain metastasis. BBB permeability was ass...

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Role:
Supervisor
Role:
Supervisor
Role:
Supervisor
Institution:
University of Oxford
Oxford college:
Wolfson College
Department:
Medical Sciences Division - Radiation,Oncology and Biology
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:8c027208-8ea6-4de4-be78-ccead5121509
Local pid:
ora:11561

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