Over one in five cancer patients will develop brain metastases and prognosis remains poor. Effective chemotherapeutics for primary systemic tumours have limited access to brain metastases owing to the blood-brain barrier (BBB). The aim of this study was to develop a strategy for specifically permeabilising the BBB at sites of cerebral metastases.
Tumour necrosis factor was injected intravenously into mouse models of haematogenously induced brain metastasis. BBB permeability was ass...Expand abstract
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- Oxford University, UK
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- John Connell
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Selective permeabilisation of the blood-brain barrier at sites of metastasis.
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