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Genomic characterization of recrudescent plasmodium malariae after treatment with artemether/lumefantrine

Abstract:

Plasmodium malariae is the only human malaria parasite species with a 72-hour intraerythrocytic cycle and the ability to persist in the host for life. We present a case of a P. malariae infection with clinical recrudescence after directly observed administration of artemether/lumefantrine. By using whole-genome sequencing, we show that the initial infection was polyclonal and the recrudescent isolate was a single clone present at low density in the initial infection. Haplotypic analysis of th...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3201/eid2308.161582

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Publisher:
Centers for Disease Control and Prevention Publisher's website
Journal:
Emerging Infectious Diseases Journal website
Volume:
23
Issue:
8
Pages:
1300-1307
Publication date:
2017-08-01
DOI:
EISSN:
1080-6059
ISSN:
1080-6040
Source identifiers:
710332
Keywords:
Pubs id:
pubs:710332
UUID:
uuid:8bff2eb7-7100-4bc7-898b-daaddc51539f
Local pid:
pubs:710332
Deposit date:
2017-08-04

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