Influenza H2 haemagglutinin activates B cells via a MyD88-dependent pathway.

Journal article

Influenza viruses are serious respiratory pathogens, responsible for half a million deaths each year. The viral surface haemagglutinin (HA) protein has been shown to be an important determinant of viral pathogenicity. HA is the virion attachment and fusion protein, and the major target for neutralizing antibodies; however, it is also involved in triggering innate responses that may have an important impact on the disease course. We have examined the role of the toll-like receptor (TLR) family...

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Authors: Marshall-Clarke, S; Tasker, L; Buchatska, O; Downes, J; Pennock, J

• Publication status: Published
• Journal: European journal of immunology
• Volume: 36
• Issue: 1
• Pages: 95-106
• Publication date: 2006-01-01
• DOI: 10.1002/eji.200535331
• EISSN: 1521-4141
• ISSN: 0014-2980
• Language: English
• Keywords: B-Lymphocytes; Humans; Animals; Myeloid Differentiation Factor 88; Leukocytes, Mononuclear; Blotting, Western; Interferons; Influenza A virus; Toll-Like Receptors; Adaptor Proteins, Signal Transducing; Hemagglutinins, Viral; Mice; Lymphocyte Activation