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Journal article

A highly restricted T-cell receptor dominates the CD8+ T-cell response to parvovirus B19 infection in HLA-A*2402-positive individuals.

Abstract:

Six of seven HLA-A*2402-positive individuals with acute parvovirus B19 infections made vigorous CD8-positive cytotoxic T-cell (CTL) responses to the viral epitope FYTPLADQF. All responders showed highly focused T-cell receptor (TCR) usage, using almost exclusively BV5.1. The BV5.1 TCR dominated the acute response, was maintained over time, and was also used by a remotely infected individual. Nine CTL clones and two oligoclonal lines obtained from three unrelated individuals used BV5.1, BJ2.1,...

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Publication status:
Published

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Publisher copy:
10.1128/jvi.02388-05

Authors


Journal:
Journal of virology More from this journal
Volume:
80
Issue:
13
Pages:
6697-6701
Publication date:
2006-07-01
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
Language:
English
Keywords:
Pubs id:
pubs:15318
UUID:
uuid:8bf3119b-c24b-4a6a-8e7a-fcfa57059345
Local pid:
pubs:15318
Source identifiers:
15318
Deposit date:
2012-12-19

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