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Plasmodium falciparum variant surface antigen expression patterns during malaria

Abstract:

The variant surface antigens expressed on Plasmodium falciparum-infected erythrocytes are potentially important targets of immunity to malaria and are encoded, at least in part, by a family of var genes, about 60 of which are present within every parasite genome. Here we use semi-conserved regions within short var gene sequence "tags" to make direct comparisons of var gene expression in 12 clinical parasite isolates from Kenyan children. A total of 1,746 var clones were sequenced from genomic...

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Journal:
PLoS Pathogens
Volume:
1
Issue:
3
Pages:
0202-0213
Publication date:
2005-01-01
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
Source identifiers:
93450
Language:
English
Pubs id:
pubs:93450
UUID:
uuid:8bf24fc1-8460-4ff6-a232-9e00d82c25d2
Local pid:
pubs:93450
Deposit date:
2012-12-19

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