NK1 receptor antagonism and emotional processing in healthy volunteers.

Journal article

The neurokinin-1 (NK(1)) receptor antagonist, aprepitant, showed activity in several animal models of depression; however, its efficacy in clinical trials was disappointing. There is little knowledge of the role of NK(1) receptors in human emotional behaviour to help explain this discrepancy. The aim of the current study was to assess the effects of a single oral dose of aprepitant (125 mg) on models of emotional processing sensitive to conventional antidepressant drug administration in 38 he...

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Authors: Chandra, P; Hafizi, S; Massey-Chase, R; Goodwin, G; Cowen, P

• Publication status: Published
• Journal: Journal of psychopharmacology (Oxford, England)
• Volume: 24
• Issue: 4
• Pages: 481-487
• Publication date: 2010-04-01
• DOI: 10.1177/0269881109103101
• EISSN: 1461-7285
• ISSN: 0269-8811
• Language: English
• Keywords: Adult; Memory; Perceptual Masking; Male; Reaction Time; Young Adult; Recognition (Psychology); Brain; Humans; Receptors, Neurokinin-1; Adolescent; Middle Aged; Emotions; Antidepressive Agents; Attention; Facial Expression; Affect; Double-Blind Method; Female; Morpholines; Cognition; Administration, Oral; Neurokinin-1 Receptor Antagonists