Acute megakaryoblastic leukaemia (AMKL) and transient myeloproliferative disorder (TMD) in Down syndrome: a multi-step model of myeloid leukaemogenesis.

Journal article

Children with Down syndrome (DS) have a marked increase in susceptibility to Acute Megakaryoblastic Leukaemia (DS-AMKL) and the closely linked neonatal preleukaemic syndrome, Transient Myeloproliferative Disorder (DS-TMD). The distinct stages of DS-TMD and DS-AMKL provide an excellent tractable model to study leukaemogenesis. This review focuses on recent studies describing clinical, haematological and biological features of DS-AMKL and DS-TMD. The findings from these studies suggest that mut...

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Authors: Roy, A; Roberts, I; Norton, A; Vyas, P

• Publication status: Published
• Journal: British journal of haematology
• Volume: 147
• Issue: 1
• Pages: 3-12
• Publication date: 2009-10-01
• DOI: 10.1111/j.1365-2141.2009.07789.x
• EISSN: 1365-2141
• ISSN: 0007-1048
• Language: English
• Keywords: Mutation; Preleukemia; Humans; Models, Genetic; Cell Transformation, Neoplastic; GATA1 Transcription Factor; Myeloproliferative Disorders; Down Syndrome; Neoplasm Proteins; Leukemia, Megakaryoblastic, Acute