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Synthetic lethality: general principles, utility and detection using genetic screens in human cells.

Abstract:

Synthetic lethality occurs when the simultaneous perturbation of two genes results in cellular or organismal death. Synthetic lethality also occurs between genes and small molecules, and can be used to elucidate the mechanism of action of drugs. This area has recently attracted attention because of the prospect of a new generation of anti-cancer drugs. Based on studies ranging from yeast to human cells, this review provides an overview of the general principles that underlie synthetic lethali...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
Journal:
FEBS letters More from this journal
Volume:
585
Issue:
1
Pages:
1-6
Publication date:
2011-01-01
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
Language:
English
Keywords:
Pubs id:
pubs:489984
UUID:
uuid:8bdbead0-4d71-4ad5-81a0-3c86f5c33bca
Local pid:
pubs:489984
Source identifiers:
489984
Deposit date:
2014-11-20

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