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Biophysical models reveal the relative importance of transporter proteins and impermeant anions in chloride homeostasis

Abstract:

Fast synaptic inhibition in the nervous system depends on the transmembrane flux of Cl- ions based on the neuronal Cl- driving force. Established theories regarding the determinants of Cl- driving force have recently been questioned. Here we present biophysical models of Cl- homeostasis using the pump-leak model. Using numerical and novel analytic solutions, we demonstrate that the Na+/K+-ATPase, ion conductances, impermeant anions, electrodiffusion, water fluxes and cation-chloride cotranspo...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.7554/eLife.39575

Authors


Düsterwald, KM More by this author
Currin, CB More by this author
Burman, RJ More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Oxford college:
Corpus Christi College
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Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
7
Pages:
e39575
Publication date:
2018-09-27
Acceptance date:
2018-09-24
DOI:
EISSN:
2050-084X
Pubs id:
pubs:922400
URN:
uri:8bdbc32f-12cf-4d77-8969-b88222169efb
UUID:
uuid:8bdbc32f-12cf-4d77-8969-b88222169efb
Local pid:
pubs:922400

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