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Circulating SFLT-1 is placentally derived in normal pregnancy

Abstract:

Excess hypoxia can lead to developmental abnormalities and antenatal deficits such as fetal intrauterine growth restriction and preeclampsia. Capillary pericytes are multifunctional cells wrapped around the vascular endothelium that play essential roles in vascular development and blood flood regulation. In vivo, brain pericytes respond to hypoxia by irreversibly constricting capillaries and thus causing cell death in rigor. To date, placental capillary pericytes (PLVP) have not been fully ch...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Women’s & Reproductive Health
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Women’s & Reproductive Health
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Women’s & Reproductive Health
Role:
Author
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Name:
Oxfordshire Health Service Research Comm
Grant:
EC/1152
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Name:
Wellcome Trust
Grant:
105605/Z/14/Z
More from this funder
Name:
Medical Research Council
Grant:
MR/J003360/1
Publisher:
Elsevier
Host title:
Placenta
Journal:
2018 International Federation of Placenta Associations Meeting (IFPA 2018) More from this journal
Volume:
69
Pages:
E48
Publication date:
2018-09-10
DOI:
EISSN:
1532-3102
ISSN:
0143-4004
Pubs id:
pubs:921711
UUID:
uuid:8bdb8a64-20a0-4091-92eb-fbcf68b6c195
Local pid:
pubs:921711
Source identifiers:
921711
Deposit date:
2018-10-02

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