Confounding effects of anesthesia on functional activation in rodent brain: a study of halothane and alpha-chloralose anesthesia.

Journal article

Functional magnetic resonance imaging (fMRI) in animal models provides a platform for more extensive investigation of drug effects and underlying physiological mechanisms than is possible in humans. However, it is usually necessary for the animal to be anesthetized. In this study, we have used a rat model of direct cortical stimulation to investigate the effects of anesthesia in rodent fMRI. Specifically, we have sought to answer two questions (i) what is the relationship between baseline neu...

Expand abstract

Authors: Austin, VC; Blamire, A; Allers, K; Sharp, T; Styles, P

• Publication status: Published
• Journal: NeuroImage
• Volume: 24
• Issue: 1
• Pages: 92-100
• Publication date: 2005-01-01
• DOI: 10.1016/j.neuroimage.2004.08.011
• EISSN: 1095-9572
• ISSN: 1053-8119
• Language: English
• Keywords: Electric Stimulation; Anesthetics, Intravenous; Halothane; Sensitivity and Specificity; Magnetic Resonance Imaging; Rats; Hindlimb; Oxygen; Anesthetics, Inhalation; Evoked Potentials, Motor; Image Processing, Computer-Assisted; Dominance, Cerebral; Isometric Contraction; Chloralose; Motor Cortex; Animals; Rats, Sprague-Dawley; Electroencephalography; Male; Anesthesia, General