Journal article

Mechanochemical approaches towards the in situ confinement of 5-FU anti-cancer drug within MIL-100 (Fe) metal–organic framework

Abstract:: We elucidate two annealing assisted mechanochemical methods to achieve one-pot encapsulation of anti-cancer drug 5-fluorouracil (5-FU) in the iron-based MIL-100 metal–organic framework (MOF). We compare the structural and physicochemical properties of drug@MIL-100 systems derived from in situ manual and vortex grinding, where the former technique exhibits a slower drug release due to stronger guest–host interactions.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Souza, B. E., & Tan, J.-C. (2020). Mechanochemical approaches towards the in situ confinement of 5-FU anti-cancer drug within MIL-100 (Fe) metal–organic framework. CrystEngComm, 22(27), 4526–4530.

MLA Style

Souza, B. E., and J.-C. Tan. “Mechanochemical Approaches towards the in Situ Confinement of 5-FU Anti-Cancer Drug within MIL-100 (Fe) Metal–Organic Framework.” CrystEngComm, vol. 22, no. 27, Royal Society of Chemistry , 2020, pp. 4526–30.

Chicago Style

Souza, BE, and J-C Tan. 2020. “Mechanochemical Approaches towards the in Situ Confinement of 5-FU Anti-Cancer Drug within MIL-100 (Fe) Metal–Organic Framework.” CrystEngComm 22 (27): 4526–30.
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Files:: d0ce00638f.pdf

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Publisher copy:: 10.1039/d0ce00638f

Authors

+ Souza, BE More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Engineering Science
Role:: Author
ORCID:: 0000-0001-6315-2149

+ Tan, J-C More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Engineering Science
Role:: Author
ORCID:: 0000-0002-5770-408X

+ European Commission More from this funder

Grant:: 771575

Publisher:: Royal Society of Chemistry
Journal:: CrystEngComm More from this journal
Volume:: 22
Issue:: 27
Pages:: 4526-4530
Publication date:: 2020-06-29
Acceptance date:: 2020-06-29
DOI:: 10.1039/d0ce00638f
EISSN:: 1466-8033

Language:: English
Keywords:: FFR
Pubs id:: 1116200
Local pid:: pubs:1116200
Deposit date:: 2020-07-03

Terms of use

Copyright holder:: Royal Society of Chemistry
Copyright date:: 2020
Rights statement:: © The Royal Society of Chemistry 2020. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence

Licence:: CC Attribution (CC BY)

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