Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes.

Journal article

An important question in human genetics is the extent to which genes causing monogenic forms of disease harbor common variants that may contribute to the more typical form of that disease. We aimed to comprehensively evaluate the extent to which common variation in the six known maturity-onset diabetes of the young (MODY) genes, which cause a monogenic form of type 2 diabetes, is associated with type 2 diabetes. Specifically, we determined patterns of common sequence variation in the genes en...

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Authors: Winckler, W; Weedon, M; Graham, R; McCarroll, SA; Purcell, S

• Publication status: Published
• Journal: Diabetes
• Volume: 56
• Issue: 3
• Pages: 685-693
• Publication date: 2007-03-01
• DOI: 10.2337/db06-0202
• EISSN: 1939-327X
• ISSN: 0012-1797
• Language: English
• Keywords: Linkage Disequilibrium; Hepatocyte Nuclear Factor 1-alpha; Female; Homeodomain Proteins; Basic Helix-Loop-Helix Transcription Factors; Diabetes Mellitus, Type 2; Polymorphism, Single Nucleotide; Genetic Variation; Humans; Genetic Predisposition to Disease; Genotype; Glucokinase; Hepatocyte Nuclear Factor 4; Male; Hepatocyte Nuclear Factor 1-beta; Trans-Activators