Journal article
Ligand-dependent downregulation of MR1 cell surface expression
- Abstract:
-
The antigen-presenting molecule MR1 presents riboflavin-based metabolites to Mucosal-Associated Invariant T (MAIT) cells. While MR1 egress to the cell surface is ligand-dependent, the ability of small-molecule ligands to impact on MR1 cellular trafficking remains unknown. Arising from an in silico screen of the MR1 ligand-binding pocket, we identify one ligand, 3-([2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl]formamido)propanoic acid, DB28, as well as an analog, methyl 3-([2,6-dioxo-1,2,3,6-tet...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- National Academy of Sciences Publisher's website
- Journal:
- Proceedings of the National Academy of Sciences Journal website
- Volume:
- 117
- Issue:
- 19
- Pages:
- 10465-10475
- Publication date:
- 2020-04-27
- Acceptance date:
- 2020-03-06
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1091871
- Local pid:
- pubs:1091871
- Deposit date:
- 2020-03-09
Terms of use
- Copyright holder:
- Salio, M et al.
- Copyright date:
- 2020
- Rights statement:
- © 2020 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY).
- Licence:
- CC Attribution (CC BY)
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