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Modeling chemotaxis reveals the role of reversed phosphotransfer and a bi-functional kinase-phosphatase

Abstract:

Understanding how multiple signals are integrated in living cells to produce a balanced response is a major challenge in biology. Two-component signal transduction pathways, such as bacterial chemotaxis, comprise histidine protein kinases (HPKs) and response regulators (RRs). These are used to sense and respond to changes in the environment. Rhodobacter sphaeroides has a complex chemosensory network with two signaling clusters, each containing a HPK, CheA. Here we demonstrate, using a mathema...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Publisher:
Public Library of Science
Journal:
PLoS Computational Biology More from this journal
Volume:
6
Issue:
8
Pages:
1657-1680
Publication date:
2010-08-19
Acceptance date:
2010-07-20
DOI:
EISSN:
1553-7358
ISSN:
1553-734X
Language:
English
Keywords:
UUID:
uuid:8bba78b2-5ee3-412a-9150-01db6071bbd2
Local pid:
pubs:71145
Source identifiers:
71145
Deposit date:
2012-12-19

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