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Prolonged amelioration of acute lung allograft rejection by overexpression of human interleukin-10 under control of a long acting ubiquitin C promoter in rats.

Abstract:

BACKGROUND: The prolonged effect of electroporation-mediated human interleukin-10 (hIL-10) overexpression in skeletal muscle under the control of the constitutional polyubiquitin C promoter (pUb hIL-10) on rat lung allograft rejection was evaluated. METHODS: Left lung allotransplantation was performed from Brown-Norway to Fischer-F344 rats. Either 2.5 mug pCIK hIL-10 (hIL-10/cytomegalovirus early promoter enhancer) alone (Group I/sacrifice Day 5 and II/sacrifice Day 10) or in combination wit...

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Authors


Stammberger, U More by this author
Gazdhar, A More by this author
Hamacher, J More by this author
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Journal:
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Volume:
25
Issue:
12
Pages:
1474-1479
Publication date:
2006-12-05
DOI:
EISSN:
1557-3117
ISSN:
1053-2498
URN:
uuid:8bb87b0f-cfa8-45e6-b087-ff9a8e29c11a
Source identifiers:
246508
Local pid:
pubs:246508

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