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Journal article

Inflammatory and myeloid-associated gene expression before and one day after infant vaccination with MVA85A correlates with induction of a T cell response.

Abstract:

BACKGROUND: Tuberculosis (TB) remains a global health problem, with vaccination likely to be a necessary part of a successful control strategy. Results of the first Phase 2b efficacy trial of a candidate vaccine, MVA85A, evaluated in BCG-vaccinated infants were published last year. Although no improvement in efficacy above BCG alone was seen, cryopreserved samples from this trial provide an opportunity to study the immune response to vaccination in this population. METHODS: We investigated bl...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/1471-2334-14-314

Authors


More by this author
Institution:
University of Oxford
Research group:
Jenner Institute
Department:
Medical Sciences Division - Clinical Vaccinology and Tropical Medicine, Centre for (CCVTM)
Role:
Author
More by this author
Institution:
University of Oxford
Research group:
Jenner Institute
Department:
Medical Sciences Division - Clinical Vaccinology and Tropical Medicine, Centre for (CCVTM)
Role:
Author
More by this author
Institution:
University of Oxford
Research group:
Jenner Institute
Department:
Medical Sciences Division - Clinical Vaccinology and Tropical Medicine, Centre for (CCVTM)
Role:
Author
More by this author
Institution:
University of Oxford
Research group:
Jenner Institute
Department:
Medical Sciences Division - Clinical Vaccinology and Tropical Medicine, Centre for (CCVTM)
Role:
Author
More by this author
Institution:
University of Oxford
Research group:
Jenner Institute
Department:
Medical Sciences Division - Clinical Vaccinology and Tropical Medicine, Centre for (CCVTM)
Role:
Author
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More from this funder
Funding agency for:
Mcshane, H
Aeras Global Tuberculosis Vaccine Foundation More from this funder
Wellcome Trust More from this funder
Oxford-Emergent Tuberculosis Consortium Limited More from this funder
Publisher:
BioMed Central Ltd. Publisher's website
Journal:
BMC infectious diseases Journal website
Volume:
14
Issue:
1
Pages:
314
Publication date:
2014-06-09
DOI:
EISSN:
1471-2334
ISSN:
1471-2334
URN:
uuid:8bb55950-b4a3-46c2-b791-11cc745cc8ea
Source identifiers:
469377
Local pid:
pubs:469377

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