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Journal article

Inflammatory and myeloid-associated gene expression before and one day after infant vaccination with MVA85A correlates with induction of a T cell response.

Abstract:

BACKGROUND: Tuberculosis (TB) remains a global health problem, with vaccination likely to be a necessary part of a successful control strategy. Results of the first Phase 2b efficacy trial of a candidate vaccine, MVA85A, evaluated in BCG-vaccinated infants were published last year. Although no improvement in efficacy above BCG alone was seen, cryopreserved samples from this trial provide an opportunity to study the immune response to vaccination in this population. METHODS: We investigated bl...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/1471-2334-14-314

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Research group:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Research group:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Research group:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Research group:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Research group:
Jenner Institute
Role:
Author
More from this funder
Name:
Wellcome Trust
Funding agency for:
Mcshane, H
More from this funder
Name:
Oxford-Emergent Tuberculosis Consortium Limited
More from this funder
Name:
Aeras Global Tuberculosis Vaccine Foundation
Publisher:
BioMed Central
Journal:
BMC infectious diseases More from this journal
Volume:
14
Issue:
1
Pages:
314
Publication date:
2014-06-09
DOI:
EISSN:
1471-2334
ISSN:
1471-2334
Language:
English
Keywords:
Subjects:
Pubs id:
pubs:469377
UUID:
uuid:8bb55950-b4a3-46c2-b791-11cc745cc8ea
Local pid:
pubs:469377
Source identifiers:
469377
Deposit date:
2014-06-30

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