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Exploring the Dynamics of the TWIK-1 Channel.

Abstract:

Potassium channels in the two-pore domain family (K2P) have various structural attributes that differ from those of other K(+) channels, including a dimeric assembly constituted of nonidentical domains and an expansive extracellular cap. Crystallization of the prototypical K2P channel, TWIK-1, finally revealed the structure of these characteristics in atomic detail, allowing computational studies to be undertaken. In this study, we performed molecular-dynamics simulations for a cumulative tim...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.bpj.2016.07.009

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Pfizer Neusentis More from this funder
Biotechnology and Biological Science Research Council More from this funder
Publisher:
Biophysical Society Publisher's website
Journal:
Biophysical journal Journal website
Volume:
111
Issue:
4
Pages:
775-784
Publication date:
2016-08-23
Acceptance date:
2016-07-11
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
Pmid:
27558721
Language:
English
Keywords:
Pubs id:
pubs:641772
UUID:
uuid:8bb0a41f-fbe2-4df1-bb60-3667952cb3c1
Local pid:
pubs:641772
Source identifiers:
641772
Deposit date:
2016-09-19

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