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Identification of anticancer drugs to radiosensitise BRAFwild-type and mutant colorectal cancer

Abstract:

Objective: Patients with BRAF-mutant colorectal cancer (CRC) have a poor prognosis. Molecular status is not currently used to select which drug to use in combination with radiotherapy. Our aim was to identify drugs that radiosensitise CRC cells with known BRAF status.

Methods: We screened 298 oncological drugs with and without ionising radiation in colorectal cancer cells isogenic for BRAF. Hits from rank product analysis were validated in a 16-cell...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher:
China Anti-Cancer Association
Journal:
Cancer Biology and Medicine More from this journal
Volume:
16
Issue:
2
Pages:
234-246
Publication date:
2019-05-01
Acceptance date:
2018-12-21
DOI:
ISSN:
2095-3941
Keywords:
Pubs id:
pubs:1014336
UUID:
uuid:8ba9301e-dda3-42ef-9c2e-7301505e8c08
Local pid:
pubs:1014336
Source identifiers:
1014336
Deposit date:
2019-06-18

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