Journal article
Identification of anticancer drugs to radiosensitise BRAFwild-type and mutant colorectal cancer
- Abstract:
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Objective: Patients with BRAF-mutant colorectal cancer (CRC) have a poor prognosis. Molecular status is not currently used to select which drug to use in combination with radiotherapy. Our aim was to identify drugs that radiosensitise CRC cells with known BRAF status.
Methods: We screened 298 oncological drugs with and without ionising radiation in colorectal cancer cells isogenic for BRAF. Hits from rank product analysis were validated in a 16-cell...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Version of record, pdf, 731.6KB)
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- Publisher copy:
- 10.20892/j.issn.2095-3941.2018.0284
Authors
Bibliographic Details
- Publisher:
- China Anti-Cancer Association Publisher's website
- Journal:
- Cancer Biology and Medicine Journal website
- Volume:
- 16
- Issue:
- 2
- Pages:
- 234-246
- Publication date:
- 2019-05-01
- Acceptance date:
- 2018-12-21
- DOI:
- ISSN:
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2095-3941
Item Description
- Keywords:
- Pubs id:
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pubs:1014336
- UUID:
-
uuid:8ba9301e-dda3-42ef-9c2e-7301505e8c08
- Local pid:
- pubs:1014336
- Source identifiers:
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1014336
- Deposit date:
- 2019-06-18
Terms of use
- Copyright holder:
- Cancer Biology and Medicine
- Copyright date:
- 2019
- Notes:
- © 2019 by Cancer Biology and Medicine. This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
- Licence:
- CC Attribution (CC BY)
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