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Salbutamol inhibits trypsin-mediated production of CXCL8 by keratinocytes.

Abstract:

Treatment of primary keratinocytes (HEKAp) with trypsin led to the production and release of CXCL8. Production of CXCL8 was exquisitely sensitive to inhibition by co-treatment with the beta(2) agonist sabutamol (IC(50)=1.1 nM). The inhibitory effect of salbutamol was beta receptor-mediated since the effect was prevented by the beta antagonist sotalol. Salbutamol also elevated intracellular levels of cAMP (EC(50)=82 nM) but the relationship to the inhibition of CXCL8 secretion was not clear-cu...

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Publisher copy:
10.1016/j.cyto.2006.10.008

Authors


Wettey, FR More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Pettipher, R More by this author
Journal:
Cytokine
Volume:
36
Issue:
1-2
Pages:
29-34
Publication date:
2006-10-05
DOI:
EISSN:
1096-0023
ISSN:
1043-4666
URN:
uuid:8ba7bdbc-eb1d-493f-8a77-4379a4bf032b
Source identifiers:
111025
Local pid:
pubs:111025

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