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Salbutamol inhibits trypsin-mediated production of CXCL8 by keratinocytes.

Abstract:

Treatment of primary keratinocytes (HEKAp) with trypsin led to the production and release of CXCL8. Production of CXCL8 was exquisitely sensitive to inhibition by co-treatment with the beta(2) agonist sabutamol (IC(50)=1.1 nM). The inhibitory effect of salbutamol was beta receptor-mediated since the effect was prevented by the beta antagonist sotalol. Salbutamol also elevated intracellular levels of cAMP (EC(50)=82 nM) but the relationship to the inhibition of CXCL8 secretion was not clear-cu...

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Publisher copy:
10.1016/j.cyto.2006.10.008

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Journal:
Cytokine
Volume:
36
Issue:
1-2
Pages:
29-34
Publication date:
2006-10-01
DOI:
EISSN:
1096-0023
ISSN:
1043-4666
Source identifiers:
111025
Language:
English
Keywords:
Pubs id:
pubs:111025
UUID:
uuid:8ba7bdbc-eb1d-493f-8a77-4379a4bf032b
Local pid:
pubs:111025
Deposit date:
2013-02-20

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