- Abstract:
-
Treatment of primary keratinocytes (HEKAp) with trypsin led to the production and release of CXCL8. Production of CXCL8 was exquisitely sensitive to inhibition by co-treatment with the beta(2) agonist sabutamol (IC(50)=1.1 nM). The inhibitory effect of salbutamol was beta receptor-mediated since the effect was prevented by the beta antagonist sotalol. Salbutamol also elevated intracellular levels of cAMP (EC(50)=82 nM) but the relationship to the inhibition of CXCL8 secretion was not clear-cu...
Expand abstract - Publisher copy:
- 10.1016/j.cyto.2006.10.008
-
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- Journal:
- Cytokine
- Volume:
- 36
- Issue:
- 1-2
- Pages:
- 29-34
- Publication date:
- 2006-10-05
- DOI:
- EISSN:
-
1096-0023
- ISSN:
-
1043-4666
- URN:
-
uuid:8ba7bdbc-eb1d-493f-8a77-4379a4bf032b
- Source identifiers:
-
111025
- Local pid:
- pubs:111025
- Language:
- English
- Keywords:
- Copyright date:
- 2006
Journal article
Salbutamol inhibits trypsin-mediated production of CXCL8 by keratinocytes.
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