Type 1 11beta-hydroxysteroid dehydrogenase as universal drug target in metabolic diseases?

Journal article

Glucocorticoid hormones play essential roles in adaptation to stress, regulation of metabolism and inflammatory responses. Their effects primarily depend on their binding to intracellular receptors leading to altered target gene transcription as well as on cell-type specific biotransformation between 11beta-hydroxy glucocorticoids and their 11-oxo metabolites. The latter effect is accomplished by two different 11beta-hydroxysteroid dehydrogenase isozymes, constituting a shuttle system between...

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Authors: Oppermann, U

• Journal: Endocrine, metabolic and immune disorders drug targets
• Volume: 6
• Issue: 3
• Pages: 259-269
• Publication date: 2006-09-01
• DOI: 10.2174/187153006778250000
• EISSN: 2212-3873
• ISSN: 1871-5303
• Language: English
• Keywords: Metabolic Syndrome X; Structure-Activity Relationship; Metabolic Diseases; Animals; Glucocorticoids; 11-beta-Hydroxysteroid Dehydrogenases; Enzyme Inhibitors; Humans