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Type 1 11beta-hydroxysteroid dehydrogenase as universal drug target in metabolic diseases?

Abstract:

Glucocorticoid hormones play essential roles in adaptation to stress, regulation of metabolism and inflammatory responses. Their effects primarily depend on their binding to intracellular receptors leading to altered target gene transcription as well as on cell-type specific biotransformation between 11beta-hydroxy glucocorticoids and their 11-oxo metabolites. The latter effect is accomplished by two different 11beta-hydroxysteroid dehydrogenase isozymes, constituting a shuttle system between...

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Publisher copy:
10.2174/187153006778250000
Journal:
Endocrine, metabolic and immune disorders drug targets More from this journal
Volume:
6
Issue:
3
Pages:
259-269
Publication date:
2006-09-01
DOI:
EISSN:
2212-3873
ISSN:
1871-5303
Language:
English
Keywords:
Pubs id:
pubs:108459
UUID:
uuid:8ba77740-34d0-4373-8433-d9aa8a0dbeda
Local pid:
pubs:108459
Source identifiers:
108459
Deposit date:
2012-12-19

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