The FtsK gamma domain directs oriented DNA translocation by interacting with KOPS.

Journal article

The bacterial septum-located DNA translocase FtsK coordinates circular chromosome segregation with cell division. Rapid translocation of DNA by FtsK is directed by 8-base-pair DNA motifs (KOPS), so that newly replicated termini are brought together at the developing septum, thereby facilitating completion of chromosome segregation. Translocase functions reside in three domains, alpha, beta and gamma. FtsKalphabeta are necessary and sufficient for ATP hydrolysis-dependent DNA translocation, wh...

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Authors: Sivanathan, V; Allen, MD; de Bekker, C; Baker, R; Arciszewska, L

• Publication status: Published
• Journal: Nature structural and molecular biology
• Volume: 13
• Issue: 11
• Pages: 965-972
• Publication date: 2006-11-01
• DOI: 10.1038/nsmb1158
• EISSN: 1545-9985
• ISSN: 1545-9993
• Language: English
• Keywords: Escherichia coli Proteins; Binding Sites; Escherichia coli; Chromosomes, Bacterial; DNA Helicases; Base Sequence; DNA-Binding Proteins; Membrane Proteins; Nuclear Magnetic Resonance, Biomolecular; Models, Molecular; Pseudomonas aeruginosa; DNA Replication; Protein Structure, Tertiary; DNA, Bacterial