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Incorporating chemical signalling factors into cell-based models of growing epithelial tissues.

Abstract:

In this paper we present a comprehensive computational framework within which the effects of chemical signalling factors on growing epithelial tissues can be studied. The method incorporates a vertex-based cell model, in conjunction with a solver for the governing chemical equations. The vertex model provides a natural mesh for the finite element method (FEM), with node movements determined by force laws. The arbitrary Lagrangian-Eulerian formulation is adopted to account for domain movement ...

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Publication status:
Published

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Publisher copy:
10.1007/s00285-011-0464-y

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Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
Journal:
Journal of mathematical biology
Volume:
65
Issue:
3
Pages:
441-463
Publication date:
2012-09-05
DOI:
EISSN:
1432-1416
ISSN:
0303-6812
URN:
uuid:8b832428-fa53-4386-a6b4-dfd587eba9ad
Source identifiers:
179656
Local pid:
pubs:179656

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