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Increased glycosphingolipid levels in serum and aortae of apolipoprotein E gene knockout mice.

Abstract:

The apolipoprotein E gene knockout (apoE-/-) mouse develops atherosclerosis that shares many features of human atherosclerosis. Increased levels of glycosphingolipid (GSL) have been reported in human atherosclerotic lesions; however, GSL levels have not been studied in the apoE-/- mouse. Here we used HPLC methods to analyze serum and aortic GSL levels in apoE-/- and C57BL/6J control mice. The concentrations of glucosyl ceramide (GlcCer), lactosyl ceramide (LacCer), GalNAcbeta1-4Galbeta1-4Glc-...

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Publication status:
Published

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Journal:
Journal of lipid research
Volume:
43
Issue:
2
Pages:
205-214
Publication date:
2002-02-05
ISSN:
0022-2275
URN:
uuid:8b82a701-4a38-41b6-9100-f41e907d0655
Source identifiers:
100960
Local pid:
pubs:100960

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