Chronic HIV infection affects the expression of the 2 transcription factors required for CD8 T-cell differentiation into cytolytic effectors.

Journal article

CD8 T cells lose the capacity to control HIV infection, but the extent of the impairment of CD8 T-cell functions and the mechanisms that underlie it remain controversial. Here we report an extensive ex vivo analysis of HIV-specific CD8 T cells, covering the expression of 16 different molecules involved in CD8 function or differentiation. This approach gave remarkably homogeneous readouts in different donors and showed that CD8 dysfunction in chronic HIV infection was much more severe than des...

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Authors: Ribeiro-dos-Santos, P; Turnbull, E; Monteiro, M; Legrand, A; Conrod, K

• Publication status: Published
• Journal: Blood
• Volume: 119
• Issue: 21
• Pages: 4928-4938
• Publication date: 2012-05-01
• DOI: 10.1182/blood-2011-12-395186
• EISSN: 1528-0020
• ISSN: 0006-4971
• Language: English
• Keywords: CD8-Positive T-Lymphocytes; Chronic Disease; Cell Differentiation; Granzymes; Fas Ligand Protein; Time Factors; HIV Infections; Case-Control Studies; T-Lymphocytes, Helper-Inducer; T-Box Domain Proteins; Transcription Factors; Humans; Interferon-gamma; Gene Expression Regulation