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Journal article

Chronic HIV infection affects the expression of the 2 transcription factors required for CD8 T-cell differentiation into cytolytic effectors.

Abstract:

CD8 T cells lose the capacity to control HIV infection, but the extent of the impairment of CD8 T-cell functions and the mechanisms that underlie it remain controversial. Here we report an extensive ex vivo analysis of HIV-specific CD8 T cells, covering the expression of 16 different molecules involved in CD8 function or differentiation. This approach gave remarkably homogeneous readouts in different donors and showed that CD8 dysfunction in chronic HIV infection was much more severe than des...

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Publication status:
Published

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Journal:
Blood More from this journal
Volume:
119
Issue:
21
Pages:
4928-4938
Publication date:
2012-05-01
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
Language:
English
Keywords:
Pubs id:
pubs:322699
UUID:
uuid:8b7cf8a6-2e2e-4508-a3e2-0d8f29fe92ce
Local pid:
pubs:322699
Source identifiers:
322699
Deposit date:
2012-12-19

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