Randomised controlled trials in primary care: case study.
All trials require a compromise between including sufficient practitioners to recruit a representative cohort of patients and the time and cost of recruiting and maintaining the motivation of these practitioners. Prior beliefs relating to the efficacy and direct or side effects of an intervention affect both doctor and patient participation. Trials in any setting are rarely fully representative with respect to both patient and disease related characteristics. Modelling, sensitivity, analysis,...Expand abstract
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