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Immunization with recombinant protein: conditions for cytotoxic T cell and/or antibody induction.

Abstract:

Safe vaccines should optimally induce both cell-mediated and humoral immunity. Recently, it has been shown that protective cytotoxic T cells (CTLs) can be induced not only with live vaccines, but also with recombinant viral proteins. This report shows in C57BL/6 (H-2b) mice that the recombinant nucleoprotein (N) of vesicular stomatitis virus (VSV) induced protective CTLs but no neutralizing antibodies in mice, whereas the recombinant glycoprotein (G) of VSV alone induced neutralizing antibodi...

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Publication status:
Published

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Publisher copy:
10.1007/bf00196682

Authors


Bachmann, MF More by this author
Hengartner, H More by this author
Zinkernagel, RM More by this author
Publisher:
Springer-Verlag
Journal:
Medical microbiology and immunology
Volume:
183
Issue:
6
Pages:
315-324
Publication date:
1994-12-05
DOI:
EISSN:
1432-1831
ISSN:
0300-8584
URN:
uuid:8b6b9efd-0013-440c-bf83-7579cd8a79cd
Source identifiers:
469187
Local pid:
pubs:469187

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