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Cell survival and proliferation are modified by insulin-like growth factor 2 between days 9 and 10 of mouse gestation.

Abstract:

The size of mammalian species involves the interaction of multiple genetic modifiers that control the timing and extent of growth mechanisms. Disruption of the paternal allele of the imprinted embryonic gene coding for insulin-like growth factor 2 (IGF2, Igf2(+m/-p)), results in viable mice that are 60% the weight of wild-type littermates. Differences in weight are first detected at embryonic day (E) 11, and the growth deficit is maintained throughout life. We report the mechanisms that accou...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology
Journal:
Development (Cambridge, England)
Volume:
128
Issue:
19
Pages:
3819-3830
Publication date:
2001-10-05
EISSN:
1477-9129
ISSN:
0950-1991
URN:
uuid:8b69cabf-4f2d-485e-b402-3dea04f153bd
Source identifiers:
458589
Local pid:
pubs:458589

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