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CXCR6 is a marker for protective antigen-specific cells in the lungs after intranasal immunization against Mycobacterium tuberculosis.

Abstract:

Convincing correlates of protective immunity against tuberculosis have been elusive. In BALB/c mice, intranasal immunization with a replication-deficient recombinant adenovirus expressing Mycobacterium tuberculosis antigen 85A (adenovirus-85A) induces protective lower respiratory tract immunity against pulmonary challenge with Mycobacterium tuberculosis, while intradermal immunization with adenovirus-85A does not. Here we report that intranasal immunization with adenovirus-85A induces express...

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Publisher copy:
10.1128/iai.01133-10

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Journal:
Infection and immunity More from this journal
Volume:
79
Issue:
8
Pages:
3328-3337
Publication date:
2011-08-01
DOI:
EISSN:
1098-5522
ISSN:
0019-9567

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