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Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women

Abstract:

Sex differences in schizophrenia are well known, but their genetic basis has not been identified. We performed a genome-wide association scan for schizophrenia in an Ashkenazi Jewish population using DNA pooling. We found a female-specific association with rs7341475, a SNP in the fourth intron of the reelin (RELIN) gene (p = 2.9 x 10⁻⁵ in women), with a significant gene-sex effect (p = 1.8 x 10⁻⁴). We studied rs7341475 in four additional populations, totaling 2,274 cases and 4,401 controls. A...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pgen.0040028

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Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Wellcome Trust Centre for Human Genetics
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Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Wellcome Trust Centre for Human Genetics
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Institution:
The Hebrew University of Jerusalem, Israel
Department:
Department of Genetics,The Institute of Life Sciences
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Institution:
Virginia Commonwealth University, Richmond, Virginia, USA
Department:
Virginia Institute for Psychiatric and Behavior Genetics
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Institution:
King's College London
Department:
Social,Genetic and Developmental Psychiatry Centre,Institute of Psychiatry
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Genetics Journal website
Volume:
4
Issue:
2
Pages:
Article: e28
Publication date:
2008-02-05
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
URN:
uuid:8b65f811-1ed2-4fff-a3a9-3b63eece999b
Local pid:
ora:3956

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