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Sleep and ageing: from human studies to rodent models

Abstract:

Sleep duration and lifespan vary greatly across Animalia. Human studies have demonstrated that ageing reduces the ability to obtain deep restorative sleep, and this may play a causative role in the development of age-related neurodegenerative disorders. Animal models are widely used in sleep and ageing studies. Importantly, in contrast to human studies, evidence from laboratory rodents suggests that sleep duration is increased with ageing, while evidence for reduced sleep intensity and consol...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.cophys.2020.03.004

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Oxford college:
Balliol College
Role:
Author
ORCID:
0000-0002-4336-6681
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Name:
Medical Research Council
Grant:
MR/L003635/1
Publisher:
Elsevier
Journal:
Current Opinion in Physiology More from this journal
Volume:
15
Article number:
210-216
Publication date:
2020-03-16
Acceptance date:
2020-03-10
DOI:
ISSN:
2468-8673
Language:
English
Keywords:
Pubs id:
1095402
Local pid:
pubs:1095402
Deposit date:
2020-03-20

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