- Abstract:
-
The therapeutic efficacy and toxicity of a high-dose (25 mg/kg) mefloquine regimen (M25) and the currently recommended regimen of 15 mg/kg (M15) were compared in 199 patients with acute falciparum malaria in an area with deteriorating multidrug resistance on the Thai-Burmese border. The clinical and parasitologic responses were significantly more rapid with M25. The incidence of treatment failures by day 7-9 was 7% for M15 and 1% for M25 (P = .03) and had increased to 40% and 9%, respectively...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1093/infdis/166.6.1393
-
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- Journal:
- The Journal of infectious diseases
- Volume:
- 166
- Issue:
- 6
- Pages:
- 1393-1400
- Publication date:
- 1992-12-05
- DOI:
- EISSN:
-
1537-6613
- ISSN:
-
0022-1899
- URN:
-
uuid:8b5b1507-a30f-4ad6-9aaa-3c233a220ef3
- Source identifiers:
-
25910
- Local pid:
- pubs:25910
- Copyright date:
- 1992
Journal article
High-dose mefloquine in the treatment of multidrug-resistant falciparum malaria.
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