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High-dose mefloquine in the treatment of multidrug-resistant falciparum malaria.

Abstract:

The therapeutic efficacy and toxicity of a high-dose (25 mg/kg) mefloquine regimen (M25) and the currently recommended regimen of 15 mg/kg (M15) were compared in 199 patients with acute falciparum malaria in an area with deteriorating multidrug resistance on the Thai-Burmese border. The clinical and parasitologic responses were significantly more rapid with M25. The incidence of treatment failures by day 7-9 was 7% for M15 and 1% for M25 (P = .03) and had increased to 40% and 9%, respectively...

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Publication status:
Published

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Publisher copy:
10.1093/infdis/166.6.1393

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Journal:
The Journal of infectious diseases
Volume:
166
Issue:
6
Pages:
1393-1400
Publication date:
1992-12-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:8b5b1507-a30f-4ad6-9aaa-3c233a220ef3
Source identifiers:
25910
Local pid:
pubs:25910

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