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Effect of 7 days of phenytoin on the pharmacokinetics of and the development of resistance to single-dose nevirapine for perinatal HIV prevention: a randomized pilot trial.

Abstract:

OBJECTIVES: To confirm whether 7 days of phenytoin, an enzyme inducer, would decrease the elimination half-life of single-dose nevirapine and to investigate its effect on the development of nevirapine resistance in pregnant, HIV-infected women. METHODS: In a pharmacokinetic pilot trial (NCT01187719), HIV-infected, antiretroviral (ARV)-naive pregnant women ≥18 years old from Zambia and Tanzania and with CD4 cell counts >350 cells/mm(3) were randomized 1 : 1 to a control (zidovudine pre-deli...

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Publication status:
Published

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Publisher copy:
10.1093/jac/dkt246

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Journal:
Journal of antimicrobial chemotherapy
Volume:
68
Issue:
11
Pages:
2609-2615
Publication date:
2013-11-01
DOI:
EISSN:
1460-2091
ISSN:
0305-7453
Source identifiers:
444408
Language:
English
Keywords:
Pubs id:
pubs:444408
UUID:
uuid:8b594fea-99c1-4e65-8f9f-80891d8cad26
Local pid:
pubs:444408
Deposit date:
2014-02-08

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