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Differential modulation of excitatory and inhibitory striatal synaptic transmission by histamine.

Abstract:

Information processing in the striatum is critical for basal ganglia function and strongly influenced by neuromodulators (e.g., dopamine). The striatum also receives modulatory afferents from the histaminergic neurons in the hypothalamus which exhibit a distinct diurnal rhythm with high activity during wakefulness, and little or no activity during sleep. In view of the fact that the striatum also expresses a high density of histamine receptors, we hypothesized that released histamine will aff...

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Publication status:
Published

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Authors


Ellender, TJ More by this author
Huerta-Ocampo, I More by this author
Deisseroth, K More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
More by this author
Institution:
University of Oxford
Department:
Oxford
Journal:
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
31
Issue:
43
Pages:
15340-15351
Publication date:
2011-10-05
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
URN:
uuid:8b592a3c-cc51-453a-a632-0cb94e5bdc49
Source identifiers:
329205
Local pid:
pubs:329205

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