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A fibrocontractive mechanochemical model of dermal wound closure incorporating realistic growth factor kinetics.

Abstract:

Fibroblasts and their activated phenotype, myofibroblasts, are the primary cell types involved in the contraction associated with dermal wound healing. Recent experimental evidence indicates that the transformation from fibroblasts to myofibroblasts involves two distinct processes: The cells are stimulated to change phenotype by the combined actions of transforming growth factor β (TGFβ) and mechanical tension. This observation indicates a need for a detailed exploration of the effect of the ...

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Publication status:
Published

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Publisher copy:
10.1007/s11538-011-9712-y

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Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
Journal:
Bulletin of mathematical biology
Volume:
74
Issue:
5
Pages:
1143-1170
Publication date:
2012-05-01
DOI:
EISSN:
1522-9602
ISSN:
0092-8240
Source identifiers:
237726
Language:
English
Keywords:
Pubs id:
pubs:237726
UUID:
uuid:8b575b28-282e-4b2f-babf-4f245731eb34
Local pid:
pubs:237726
Deposit date:
2013-11-17

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