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A fibrocontractive mechanochemical model of dermal wound closure incorporating realistic growth factor kinetics.

Abstract:

Fibroblasts and their activated phenotype, myofibroblasts, are the primary cell types involved in the contraction associated with dermal wound healing. Recent experimental evidence indicates that the transformation from fibroblasts to myofibroblasts involves two distinct processes: The cells are stimulated to change phenotype by the combined actions of transforming growth factor β (TGFβ) and mechanical tension. This observation indicates a need for a detailed exploration of the effect of the ...

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Publication status:
Published

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Publisher copy:
10.1007/s11538-011-9712-y

Authors


Murphy, KE More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
McElwain, DL More by this author
Journal:
Bulletin of mathematical biology
Volume:
74
Issue:
5
Pages:
1143-1170
Publication date:
2012-05-05
DOI:
EISSN:
1522-9602
ISSN:
0092-8240
URN:
uuid:8b575b28-282e-4b2f-babf-4f245731eb34
Source identifiers:
237726
Local pid:
pubs:237726

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