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Microvesicles from malaria-infected red blood cells activate natural killer cells via MDA5 pathway

Abstract:

Natural killer (NK) cells provide the first line of defense against malaria parasite infection. However, the molecular mechanisms through which NK cells are activated by parasites are largely unknown, so is the molecular basis underlying the variation in NK cell responses to malaria infection in the human population. Here, we compared transcriptional profiles of responding and non-responding NK cells following exposure to Plasmodium-infected red blood cells (iRBCs) and identified MDA5, a RIG-...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.ppat.1007298

Authors


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Role:
Author
ORCID:
0000-0002-3247-0686
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Role:
Author
ORCID:
0000-0001-9913-8365
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Tropical Medicine
Role:
Author
ORCID:
0000-0002-0482-5689
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National Research Foundation of Singapore More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Pathogens Journal website
Volume:
14
Issue:
10
Pages:
e1007298
Publication date:
2018-10-04
Acceptance date:
2018-08-26
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
Pubs id:
pubs:923832
URN:
uri:8b536bed-a0b3-494f-9dd9-6d1ac5ca6b48
UUID:
uuid:8b536bed-a0b3-494f-9dd9-6d1ac5ca6b48
Local pid:
pubs:923832
Language:
English
Keywords:

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