The size of the synaptic cleft and distinct distributions of filamentous actin, ezrin, CD43, and CD45 at activating and inhibitory human NK cell immune synapses.

Journal article

In this study, we report the organization of cytoskeletal and large transmembrane proteins at the inhibitory and activating NK cell immunological or immune synapse (IS). Filamentous actin accumulates at the activating, but not the inhibitory, NK cell IS. However, surprisingly, ezrin and the associated protein CD43 are excluded from the inhibitory, but not the activating, NK cell IS. This distribution of ezrin and CD43 at the inhibitory NK cell IS is similar to that previously seen at the acti...

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Authors: McCann, F; Vanherberghen, B; Eleme, K; Carlin, L; Newsam, R

• Publication status: Published
• Journal: Journal of Immunology
• Volume: 170
• Issue: 6
• Pages: 2862-2870
• Publication date: 2003-03-01
• DOI: 10.4049/jimmunol.170.6.2862
• EISSN: 1550-6606
• ISSN: 0022-1767
• Language: English
• Keywords: Receptors, KIR2DL1; Receptors, Immunologic; Cytotoxicity, Immunologic; Cell Line, Transformed; Microscopy, Immunoelectron; Cytoskeletal Proteins; Antigens, CD; Actin Cytoskeleton; Intercellular Junctions; Tumor Cells, Cultured; Actins; Killer Cells, Natural; Clone Cells; Microscopy, Confocal; Lymphocyte Activation; Humans; Antigens, CD43; Antigens, CD45; Sialoglycoproteins; HLA-C Antigens; Phosphoproteins; Cell Communication