Journal article icon

Journal article

Screening blockers against a potassium channel with a droplet interface bilayer array.

Abstract:

Droplet interface bilayers (DIBs) form between two lipid monolayer-encased aqueous droplets submerged in oil. Both major structural classes of membrane proteins, alpha-helix bundles and beta barrels, represented by channels and pores, respectively, spontaneously insert into DIBs when freshly expressed by cell-free transcription and translation. Electrodes embedded within the droplets allow the measurement of transmembrane ionic currents carried by individual channels and pores. On the basis o...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1021/ja804968g
Journal:
Journal of the American Chemical Society More from this journal
Volume:
130
Issue:
46
Pages:
15543-15548
Publication date:
2008-11-01
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
Language:
English
Keywords:
Pubs id:
pubs:52259
UUID:
uuid:8b4d44ab-1d20-45f2-971e-872cfcd46360
Local pid:
pubs:52259
Source identifiers:
52259
Deposit date:
2013-11-16

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP