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White matter hyperintensities classified according to intensity and spatial location reveal specific associations with cognitive performance

Abstract:

White matter hyperintensities (WMHs) on T2-weighted images are radiological signs of cerebral small vessel disease. As their total volume is variably associated with cognition, a new approach that integrates multiple radiological criteria is warranted. Location may matter, as periventricular WMHs have been shown to be associated with cognitive impairments. WMHs that appear as hypointense in T1-weighted images (T1w) may also indicate the most severe component of WMHs. We developed an automatic...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


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Name:
European Commission
Grant:
732592
More from this funder
Name:
Medical Research Council
Grant:
G1001354
More from this funder
Name:
Gordon Small Charitable Trust
Grant:
AJP/DH/S.0791.000
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Name:
National Institutes of Health
Publisher:
Elsevier
Journal:
NeuroImage: Clinical More from this journal
Volume:
30
Article number:
102616
Publication date:
2021-03-07
Acceptance date:
2021-02-27
DOI:
EISSN:
2213-1582
Language:
English
Keywords:
Pubs id:
1163704
Local pid:
pubs:1163704
Deposit date:
2021-02-27

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