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Matrix metalloproteinase-2 production and its binding to the matrix are increased in abdominal aortic aneurysms.

Abstract:

Degradation of the elastic media is a hallmark of abdominal aortic aneurysms (AAAs). We examined the expression of 2 elastolytic matrix metalloproteinases (MMPs), MMP-2 and MMP-9, in AAA aortic tissues compared with those from atherosclerotic occlusive disease (AOD) and nondiseased control tissues. Quantitative competitive reverse transcription-polymerase chain reaction and gelatin zymography showed increased MMP-9 mRNA and protein in both AAA and AOD tissues compared with those in control ti...

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Publisher copy:
10.1161/01.atv.18.10.1625

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
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Journal:
Arteriosclerosis, thrombosis, and vascular biology
Volume:
18
Issue:
10
Pages:
1625-1633
Publication date:
1998-10-01
DOI:
EISSN:
1524-4636
ISSN:
1079-5642
Source identifiers:
411390
Language:
English
Keywords:
Pubs id:
pubs:411390
UUID:
uuid:8b433cc9-f3a2-4164-af5d-5cc961ddc223
Local pid:
pubs:411390
Deposit date:
2014-02-14

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