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Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo.

Abstract:

While memory T cells are maintained by continuous turnover, it is not clear how human regulatory CD4+ CD45RO+ CD25hi Foxp3+ T lymphocyte populations persist throughout life. We therefore used deuterium labeling of cycling cells in vivo to determine whether these cells could be replenished by proliferation. We found that CD4+ CD45RO+ Foxp3+ CD25hi T lymphocytes were highly proliferative, with a doubling time of 8 days, compared with memory CD4+ CD45RO+ Foxp3- CD25- (24 days) or naive CD4+ CD45...

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Publisher copy:
10.1172/jci28941

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Journal:
The Journal of clinical investigation
Volume:
116
Issue:
9
Pages:
2423-2433
Publication date:
2006-09-05
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
URN:
uuid:8b3e5c99-d1c1-4f27-863b-28510df94f64
Source identifiers:
33590
Local pid:
pubs:33590

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